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© Virginie Courtier-Orgogozo’s group papers
® Michael Rera’s group papers
Ⓥ Roshan Vijendravarma’s group papers

In preparation or in review

© Monier M, Lorenzi JN, Narasimha S, Borne F, Contremoulins V, Mevel L, Petit R, Graner F and Courtier-Orgogozo V. Drosophila glue evolved different adhesive and mechanical properties across 50 million years. Submitted. BioRxiv Sup

© Nagy O et al. Hypandrial genital bristles facilitate phallus intromission in D. melanogaster. In preparation.

® Roget, T., MacMurray, C., Jolivet, P., Méléard, S., & Rera, M. (2023). A scenario for an evolutionary selection of ageing. In review. BioRxiv

® Martins, R. R., Rera, M., & Henriques, C. M. Transcriptomics signatures of telomerase-dependent and -independent ageing, in the Zebrafish gut and brain. BioRxiv, 2022-05.

© Lefèvre BM, Delvigne M, Vidal J, Courtier-Orgogozo V, Lang M. A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID. doi: 10.1101/2022.01.16.476383 BioRxiv


© Lorenzi JN, Graner F, Courtier-Orgogozo V, Achaz G. CNCA aligns small annotated genomes. BMC Bioinformatics, 25(1), 89. doi: 10.1186/s12859-024-05700-1 Zenodo

© Monier M., Nuez I., Borne F., Courtier-Orgogozo V (2024) Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences. BMC Ecology and evolution 24, 18. doi: 10.1186/s12862-023-02178-y Research Square PDF DRYAD


© Chai D., Mossadeq L.E., Raymond M., Courtier-Orgogozo V (2023) Recommended distances for physical distancing during COVID-19 pandemics reveal cultural connections between countries. PLoS ONE 18(12): e0289998. doi: 10.1371/journal.pone.0289998 MedRxiv
Presented by Le Figaro

® Zane, F., Bouzid, H., Marmol, S. S., Besse, S., Molina, J. L., Cansell, C., … & Rera, M. (2023). Smurfness-based two-phase model of ageing helps deconvolve the ageing transcriptional signature. Aging Cell, 2022-11. doi: 10.1111/acel.13946 BioRxiv

® Cansell, C., Goepp, V., Bain, F., Todd, N., Douard, V., Monnoye, M., … & Rera, M. (2023) Two phases model of ageing in mice: towards a better identification of age-related and late-life metabolic decline. [Registered Report Stage 1 Protocol] Registered at BMC Biology.

® Abakarova, M., Marquet, C., Rera, M., Rost, B., & Laine, E. (2023). Alignment-based protein mutational landscape prediction: doing more with less. Genome Biology and Evolution, evad201. BioRxiv

Ⓥ Vijendravarma, R. K. (2023). Diverse strategies that animals use to deter intraspecific predation. Journal of Evolutionary Biology, 36(7), 967-974. doi: 10.1111/jeb.14129

© Courtier-Orgogozo V (2023) The Loci of Insect Phenotypic Evolution. Current Opinion in Insect Science 60, 101134. doi: 10.1016/j.cois.2023.101134 PDF BioRxiv

© Elkin J, Martin A, Courtier-Orgogozo V, Santos ME (2023) Analysis of the genetic loci of pigment pattern evolution in vertebrates. Biological Reviews. doi: 10.1101/2022.01.01.474697  BioRxiv


© Monier M, Courtier-Orgogozo V (2022) Drosophila glue: a promising model for bioadhesion. Insects 13, 734. doi:10.3390/insects13080734. Supp Material  Scholarly Community Encyclopedia

Ⓥ Vijendravarma, R. K., Narasimha, S., Steinfath, E., Clemens, J., & Leopold, P. (2022). Drosophila females have an acoustic preference for symmetric males. PNAS, 119(13), e2116136119.

© van Gammeren S, Lang M, Ruecklin M, Schilthuizen M (2022) No evidence for asymmetric sperm deposition in a species with asymmetric male genitalia. Peer J. doi1:10.7717/peerj.14225 doi2:10.1101/2022.03.19.485007 BioRxiv

© Courtier-Orgogozo V, de Ribera F (2022) SARS-CoV-2 infection at the Huanan seafood market. Environmental research 214:113702. doi:10.1016/j.envres.2022.113702 Zenodo

© Kitano J, Ishikawa A, Ravinet M, Courtier-Orgogozo V (2022) Speciation and adaptation genes: From loci to causative mutations. Phil. Trans B. doi:10.1098/rstb.2020.0503.

© McQueen E, Afkhami M, Atallah J, Gompel N, Heifetz Y, Kamimura Y, … & Yassin A (2022). A Standardized Nomenclature and Atlas of the Female Terminalia of Drosophila melanogaster. Fly. doi:10.1080/19336934.2022.2058309. HAL Preprints

© Lefèvre BM, Mienanzambi S & Lang M (2022). Developmental timing of Drosophila pachea pupae is robust to temperature changes. Journal of Thermal Biology 106, 103232. doi:10.1186/s12862-021-01759-z  PDF BioRxiv


Borne F, Kulathinal RJ, Courtier-Orgogozo V (2021) Glue genes are subjected to diverse selective forces during Drosophila development. Genome Biology and Evolution. evab248. doi:10.1093/gbe/evab248 PDF  DRYAD BioRxiv.

Suvorov, A., Kim, B. Y., Wang, J., Armstrong, E. E., Peede, D., D’Agostino, E. R., Price, D.K., Waddell, P., Lang, M., Courtier-Orgogozo, V., David, J.R., Petrov, P., Matute, D.R., Schrider, D.R., Comeault, A. A. (2021) Widespread introgression across a phylogeny of 155 Drosophila genomes. Current Biology 32, 1-13. doi:10.1016/j.cub.2021.10.052 BioRxiv

van Helden, J., Butler, C. D., Achaz, G., Canard, B., Casane, D., Claverie, J. M., … & Halloy, J. (2021) An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2. The Lancet 398:1402-1404. doi: 10.1016/S0140-6736(21)02019-5  Featured in several newspapers including   il Fatto Quotidiano Daily Mail ThePrint   

Peluffo AE, Hamdani M, Vargas-Valderrama A, David JR, Mallard F, Graner F, Courtier-Orgogozo V. (2021) A morphological trait involved in reproductive isolation between Drosophila sister species is sensitive to temperature. Ecology and Evolution 11(12), 7492-7506. doi: 10.1002/ece3.7580 DRYAD Supp Data BioRxiv 

Borne, F., Prigent, S.R., Molet, M., Courtier-Orgogozo, V. (2021) Drosophila glue protects from predation. Proc. R. Soc. B. 288: 20210088. doi: 10.1098/rspb.2021.0088 DRYAD Supp Data  BioRxiv
Actualité CNRS

Lefèvre, B.M., Catté, D., Courtier-Orgogozo, V., Lang, M. (2021) Male genital lobe morphology affects the chance to copulate in Drosophila pachea. BMC Ecol Evo 21, 23. doi: 10.1186/s12862-021-01759-z PDF


Rode N, Courtier-Orgogozo V, Débarre F. (2020) Can a population targeted by a CRISPR-based homing gene drive be rescued? G3. 10 (9), 3403-3415. doi: 10.1534/g3.120.401484 BioRxiv

Courtier-Orgogozo V, Danchin A, Gouyon PH, Boëte C (2020) Evaluating the Probability of CRISPR-based Gene Drive Contaminating Another Species. Evolutionary Applications 00:1–18. doi: 10.1111/eva.12939 BioRxiv PDF

Borne F, Kovalev A, Gorb S, Courtier-Orgogozo V (2020) The glue produced by Drosophila melanogaster for pupa adhesion is universal. Journal of Experimental Biology 223: jeb220608 doi: 10.1242/jeb.220608 Published 23 April 2020. DRYAD BioRxiv Featured in “inside JEB. PDF
Passion Entomologie

Courtier-Orgogozo V, Martin A (2020) The Coding Loci of Evolution and Domestication: Current Knowledge and Implications for Bio-Inspired Genome Editing. Journal of Experimental Biology 223: jeb208934. Published 7 February 2020. doi: 10.1242/jeb.208934 Supp Data Script  PDF  HAL

Prigent S, Lang M, Nagy O, Acurio A, Matamoro-Vidal A, Courtier-Orgogozo and David JR (2020) Field collections reveal that São Tomé is the Afrotropical island with the highest diversity of drosophilid flies (Diptera: Drosophilidae). Annales de la Société Entomologique de France. doi:10.1080/00379271.2019.1703814 PDF HAL

Courtier-Orgogozo V, Martin A, Arnoult L, Prigent S, Wiltgen S (2020) Gephebase, a Database of Genotype-Phenotype Relationships for natural and domesticated variation in Eukaryotes. Nucleic Acid Research 48(D1), D696-D703. doi:10.1093/nar/gkz796 PDF HAL BioRxiv


Fly-genitalia-atlas-CoverGavin Rice, Jean R. David, Yoshitaka Kamimura, John P. Masly, Alistair P. Mcgregor, Olga Nagy, Stéphane Noselli, Maria Daniela Santos Nunes, Patrick O’Grady, Ernesto Sánchez-Herrero, Mark L. Siegal, Masanori J. Toda*, Mark Rebeiz*, Virginie Courtier-Orgogozo*, Amir Yassin* (*: corresponding authors) (2019). Revised nomenclature and atlas of the male terminalia of Drosophila melanogaster. Fly. doi:10.1080/19336934.2019.1653733 PDF HAL preprints 

Matentzoglu, Nicolas, Balhoff, James P., Bello, Susan M., Bradford, Yvonne M., Carmody, Leigh C., Cooper, Laurel D., Courtier-Orgogozo V., … Osumi-Sutherland, David. (2019, July 26). Phenotype Ontologies Traversing All The Organisms (POTATO) workshop: 2nd edition. Zenodo

Acurio A, Rhebergen FT, Paulus S, Courtier-Orgogozo V, Lang M (2019) Repeated evolution of asymmetric genitalia and one-sided mating in the Drosophila nannoptera species group. BMC Evolutionary Biology 19:109. doi:10.1186/s12862-019-1434-z  HAL PDF bioRxiv

Pondeville E, Puchot N, Lang M, Cherrier F, Schaffner F, Dauphin-Villemant C, Bischoff E, and Bourgouin C (2019) Evolution of sexually-transferred steroids and mating-induced phenotypes in Anopheles mosquitoes. Science Reports 2019, 9:4669.

Rode NO, Estoup A, Bourguet D, Courtier-Orgogozo V, Débarre F (2019) Population management using gene drive: molecular design, models of spread dynamics and assessment of ecological risks. Conservation Genetics, 20: 671–690. PDF Zenodo

Da Lage JL, Thomas GWC, Bonneau M, Courtier-Orgogozo V (2019) Evolution of salivary glue genes in Drosophila species. BMC Evolutionary Biology 19:36. PDF bioRxiv


Nagy O, Nuez I, Savisaar R, Peluffo AE, Yassin A, Lang M, Stern DL, Matute DR, David JR, Courtier-Orgogozo V. Correlated Evolution of two Copulatory Organs via a Single Cis-Regulatory Nucleotide Change. Current Biology 28(21):3450-3457.e13. doi: 10.1016/j.cub.2018.08.047. Epub 2018 Oct 18. Supp Info FigShare PDF
HAL bioRxiv  Youtube videoCNRS newsLa RechercheDispatch in Current BiologyF1000 RecommendationOpenAccess

Matamoro-Vidal A, Tully T, Courtier-Orgogozo V, Robustness of bristle number to temperature and genetic background varies with bristle type and is regulated by miR-9a. bioRxiv

Courtier-Orgogozo V, Martin A, Predicting the genetic loci of past evolution. To be published in The culture of predictability and the nature of the unpredictable. Life, evolution, behaviour. Eds. Ceccarelli D, Frezza G. PDF Full Book bioRxiv


Courtier-Orgogozo V, Morizot B, Boëte C, Using CRISPR‐based gene drive for agriculture pest control. EMBO reports 18, 1481. Reply to Comments. PDF

Courtier-Orgogozo V, Morizot B, Boëte C, Agriculture Pest Control with CRISPR-based gene drive: Time for public debate. EMBO reports . PDF

Martin A, Courtier-Orgogozo V, Morphological evolution repeatedly caused by mutations in signaling ligand genes. Diversity and Evolution of Butterfly Wing Patterns : An Integrative Approach. Eds. Sekimura T, Nijout F. Springer. Book chapter Table S1 Table S2 PDF

Rhebergen F, Courtier-Orgogozo V, Dumont J, Schilthuizen M, Lang M. (2016) Drosophila pachea asymmetric lobes are part of a grasping device and stabilize one-sided mating. BMC Evolutionary Biology, 16(1),176. HAL PDF

Orgogozo V, Peluffo A, Morizot B. (2016) The “Mendelian gene” and the “molecular gene”: two relevant concepts of genetic units. Current Topics in Developmental Biology 119:1-26. CTDB HAL PDF

Lang M, Nagy O, Lang C, Orgogozo V. (2016) High throughput preparation of fly genomic DNA in 96-well format using a paint-shaker. Fly 9(3):138-44. PubMed PDF

Pradeu T, Laplane L, Prévot K, Hoquet T, Reynaud V, Fusco G, Minelli A, Orgogozo V, and Vervoort M. (2016) Defining “development”. Current Topics in Developmental Biology 117:171-83. Link PDF

Orgogozo, V. (2015). Replaying the tape of life in the twenty-first century. Interface Focus, 5(6), 20150057. PDF

Orgogozo, V, Morizot, B, & Martin, A (2015). The differential view of genotype–phenotype relationships. Frontiers in Genetics, 6, 179. PDF

Peluffo, A. E., Nuez, I., Debat, V., Savisaar, R., Stern, D. L., & Orgogozo, V. (2015). A Major Locus Controls a Genital Shape Difference Involved in Reproductive Isolation Between Drosophila yakuba and Drosophila santomea. G3: Genes| Genomes| Genetics, g3-115. PDF

Lang, M., Polihronakis Richmond, M., Acurio, A. E., Markow, T. A., & Orgogozo, V. (2014). Radiation of the Drosophila nannoptera species group in Mexico. Journal of Evolutionary Biology, 27(3), 575-584. PDF

Orgogozo V, Martin A, Evolution and Development: Genes and Mutations Underlying Phenotypic Variation. In Oxford Bibliographies in Evolutionary Biology. Ed. Jonathan Losos. New York: Oxford University Press. Oxford Bibliographies. Full Text

Martin A, Orgogozo V, The loci of repeated evolution: a catalogue of genetic hotspots of phenotypic variation. Evolution 67(5):1235–1250. PDF Supp database

Yassin A, Orgogozo V, Coevolution between Male and Female Genitalia in the Drosophila melanogaster Species Subgroup. PLoS ONE 2013;8(2):e57158. Full text PDF

Yassin A. Phylogenetic classification of the Drosophilidae Rondani (Diptera): the role of morphology in the postgenomic era. Systematic Entomology 38, 349–364.

Lang M, Murat S, Clark AG, Gouppil G, Blais C, Matzkin LM, Guittard E, Yoshiyama-Yanagawa T, Kataoka H, Niwa R, Lafont R, Dauphin-Villemant C and Orgogozo V, Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.
Science 2012 Sep 28;337(6102):1658-61. Full Text PDF Supporting Online Material
Commentaries in :
Current Biology The Scientist Blog Discover Magazine
Neue Zürcher Zeitung Scienceticker Umwelt
Communiqué de presse CNRS
Sciences et Avenir

Yassin A, Gidaszewskib N,Albert B,Hivert J, Rast A,David JR,Orgogozo V, Debat V, The Drosophilidae (Diptera) of the Sparse Islands, with the Description of a Novel Association with Leptadenia madagascariensis Decne (Apocynaceae). Fly. 2012; 6(4). 2012 Oct-Dec;6(4):298-302.

Lang M, Orgogozo V, Distinct copulation positions in Drosophila pachea males with symmetric or asymmetric external genitalia. Contributions to Zoology. 2012; 81:87-94. PDF

Orgogozo V, Rockman M (editors), Molecular Methods in Evolutionary Biology. Humana Press (Springer). 2011. Table of contents

Lang M, Orgogozo V, Identification of homologous gene sequences by PCR with degenerate oligonucleotides. Book chapter in Molecular methods in Evolutionary Biology. Humana Press (Springer) 2011.

Stern DL, Orgogozo V, How different are recently diverged species?: more than 150 phenotypic differences have been reported for the D. melanogaster species subgroup. Fly. 2009 Apr-Jun;3(2):117. Epub 2009 May 1. PubMed

Stern DL, Orgogozo V, Is genetic evolution predictable? Science. 2009 Feb 6;323(5915):746-51. PubMed

Stern DL, Orgogozo V, The loci of evolution: how predictable is genetic evolution? Evolution. 2008 Sep;62(9):2155-77. Epub 2008 Jul 4.  PubMed Appendix References for appendix

McGregor AP, Orgogozo V, Delon I, Zanet J, Srinivasan DG, Payre F, Stern DL, Morphological evolution through multiple cis-regulatory mutations at a single gene. Nature. 2007 Aug 2;448(7153):587-90. Epub 2007 Jul 15. PubMed

Orgogozo V, Muro NM, Stern DL, Variation in fiber number of a male-specific muscle between Drosophila species: a genetic and developmental analysis. Evolution and Development. 2007 Jul-Aug;9(4):368-77.PubMed

Orgogozo V, Stern DL, Thirty-three new mutations in D. simulans. Drosophila Information Service 2006. PDF

Orgogozo V, Broman KW, Stern DL, High-resolution QTL Mapping Reveals Sign Epistasis Controlling Ovariole Number between two Drosophila species. Genetics. 2006 May;173(1):197-205. Sup. Data Sup. Table 1 Sup. Table 2 Sup. Table 3 PubMed

Orgogozo V, Grueber WB, FlyPNS, a database of the Drosophila embryonic and larval peripheral nervous system. BMC Dev Biol. 2005 Feb 17; 5(1):4. PubMed   PDF

Orgogozo V, Schweisguth F, Evolution of the larval peripheral nervous system in Drosophila species has involved a change in sensory cell lineage. Dev Genes Evol. 2004 Sep; 214(9):442-52. PubMed selected by Faculty of 1000

Orgogozo V, Schweisguth F, Bellaiche Y, Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila. Mech Dev. 2004 May;121(5):427-36. PubMed

Lai EC, Orgogozo V, A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity. Dev Biol. 2004 May;269(1):1-17. PubMed

Orgogozo V, Formation des organes sensoriels chez D. melanogaster : lignages cellulaires, apoptose et evolution. 2003 Thèse (en français) PDF

Orgogozo V, Schweisguth F, Bellaiche Y, Binary cell death decision regulated by unequal partitioning of Numb at mitosis. Development. 2002 Oct;129(20):4677-84. PubMed

Orgogozo V, Schweisguth F, Bellaiche Y, Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo. Development. 2001 Mar;128(5):631-43. PubMed

[..] les mots sont des étiquettes collées sur les choses, les mots ne sont pas les choses, tu ne sauras jamais comment sont les choses, pas même quels sont leurs vrais noms, car les noms que tu leur donnes ne sont que cela, les noms que toi tu leur donnes. (José Saramago)